• Emily as Susan/Ginormica (Emily and Susan/Ginormica are both the main females)
  • James as Missing Link (James and Missing Link are both vain)
  • Thomas as Dr Cockroach (Thomas and Dr Cockroach are both cheeky)
  • Percy as Bob (Percy and Bob are both funny)
  • Diesel as Gallaxhar (Diesel and Gallaxhar are both the main villains)
  • Diesel 10 as Insectosaurus (Diesel 10 and Insectosaurus are both big, strong, and powerful)
  • Cerberus (from The Little Engine That Could '2011 Film') as Alien Clone Robot (Cerberus and Alien Clone Robot are both big, strong, evil, and powerful)
  • Smudger as Gallaxhar's Clone 1 (Smudger and Gallaxhar's Clone 1 are both evil and mean to Emily and Susan/Ginormica)
  • Bad Diesel and Troublesome Trucks as Gallaxhar's Clones
  • Donald/Douglas as Hathaway
  • Boco as Monger (Boco and Monger are both wise and kind)
  • Edward and Molly as Carl and Wendy Murphy
  • Mavis as Computer
  • Oliver as News Reporter
  • Flora as Katie
  • Derek as Derek (Derek and Derek are both share the same names)
  • Casey Jr (from Disney's Dumbo/Casey Jr and Friends) as Marco
  • Bill/Ben as Reverend

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