- Carl Fredrickson as Garfield
- Dug as Odie
- Young Carl Fredrickson as Nermal
- Dave Seville (from Alvin and the Chipmunks) as Jon Arbuckle
- Ellie Fredrickson as Arlene
- Steve Urkel (from Family Matters) as Orson
- Laura Winslow (from Family Matters) as Lanolin
- Alpha as The Weasel
- Fred (from Fred) as Roy
- Charles F. Muntz as The Wolf
- Tom the Foreman as The Old Pig
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