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- Bart (from The Simpsons) as Calvin
- Wade's Dad as Hobbes
- Daisy (from TTTE) as Susie
- Brianna as Calvin's Mom
- Wade as Calvin's Dad
- Zira (from The Lion King) as Rosalyn
- Uncle Ed as Charlie
- Sally Seaplane (from TUGS) as Calvin's Teacher
- Big Mac (from TUGS) as Calvin's Principal
- Zeke as Calvin's Dummy
- Wade's Mom as Hobbes's Girlfriend
- and more