- Johnny Cash as Homer Simpson
- June Carter Cash as Marge Simpson
- Vivian Liberto as Lisa Simpson
- Ray Cash as Bart Simpson
- Rosanne Cash as Selma Bouvier
- Sam Phillips as Ned Flanders
- Luther Perkins as Waylon Smithers, Jr.
- Marshall Grant as Kent Brockman
- Shelby Lynne as Maude Flanders
- Elvis Presley as Mayor Joe Quimby
- Jerry Lee Lewis as Dr. Julius Hibbert
- Waylon Jennings as Lenny
- Fluke Holland as Carl
- Roy Orbison as Officer Lou
- Jack Cash as Principal Seymour Skinner
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