• Homer Simpson as Rex
  • Ned Flanders as Woog
  • Bart Simpson as Dweeb
  • Marge Simpson as Elsa
  • Milhouse as Louie
  • Lisa Simpson as Cecilia
  • Grandpa Abe as Captain Neweyes
  • Krusty as Stubbs
  • Mr. Burns as Professor Screweyes
  • Maude Flanders as Dr. Bleeb
  • Young Simba (from The Lion King) as Buster
  • Adult Nala (from The Lion King) as Buster's Mother
  • Mufasa (from The Lion King) as Buster's Father

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