Who Framed Streaky the Supercat is Youknowhatmoviesucks' movie-spoof of "Who Framed Roger Rabbit".
Roger Rabbit - Streaky the Supercat (Krypto the Superdog)
Eddie Valiant - Tulio (The Road to El Dorado; w/ Miguel as an extra)
Baby Herman - Tails (Sonic X)
Jessica Rabbit - Kate (Alpha & Omega)
Dolores - Chel (The Road to El Dorado)
Judge Doom - Clayton (Tarzan)
Smarty Weasel - Scarface (Animals of Farthing Wood)
Greasy Weasel - Carface (All Dogs Go to Heaven)
Wheezy Weasel - Killer (All Dogs Go to Heaven)
Stupid Weasel - Bud (Krypto the Superdog)
Psycho Weasel - Lou (Krypto the Superdog)
Benny the Cab - Tantor (Tarzan)
R.K. Maroon - Gaston (Beauty and the Beast)
Marvin Acme - Genie (Aladdin)
Mickey Mouse - Winnie the Pooh
Donald Duck - Spike (My Little Pony: Friendship Is Magic)
Bugs Bunny - Sonic the Hedgehog
Daffy Duck - Blu (Rio)
Dumbo - Rainbow Dash (My Little Pony: Friendship Is Magic)
Bongo the Gorilla - Tublat (The Legend of Tarzan)
Yosemite Sam - Dr. Robotnik (The Adventures of Sonic the Hedgehog)
Tweety - Robbie the Robin (Krypto the Superdog)
Goofy - Tigger (Winnie the Pooh)
Droopy - Dodger (Oliver & Company)
Betty Bop - Zoe Trent (Littlest Pet Shop (2012))
Cartoon Judge Doom - Red the Dragon (Spyro)
Hyacinth Hippo - Kanga (Pooh)
Unlucky Shoe - Pinky (Animaniacs)
Mrs. Herman - Vixen (Animals of Farthing Wood)
Woody Woodpecker - Boomer (with Dinky as an extra) (The Fox and the Hound)
Pinocchio - Scamp (Lady and the Tramp: Scamp's Adventure)
Lena Hyena - Sour Kangaroo (Horton Hears A Who!)
Singing Sword - Lumiere (Beauty and the Beast)
Bullets - Flik, Francis, Slim and Heimlich (A Bug's Life)
Minnie Mouse - ???
Porky Pig - Pumbaa (The Lion King)
Octopus Bartender - ???
Mr. Toad - Mushu (Mulan)
Hummingbirds - ???
Tinker Bell - Pepper Clark (Littlest Pet Shop)
The reason why Kate is playing Jessica Rabbit instead of Princess, Streaky's canon love interest from Kypto the Superdog is because youknowwhatmoviesucks believes that it would ruin the interspecies relationship from the movie.
youknowwhatmoviesucks wanted to use Discord from My Little Pony: Friendship Is Magic as Toon Judge Doom, but a lot of other users were already using him.