Wilson, M
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[edit] In Memory
[edit] Patient Information
Age: 14
Sex: Male
Diagnosed: 03/05
Location: Tennessee
Diagnosis: Disease around intestines, in a cluster of lymph nodes between bladder and rectum, and a small area in chest. DSRCT
Hospital - Vanderbilt Childrens Hospital
Passed Away: 07/25/05
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[edit] Treatment
Dose-Intensification for Pediatric Patients:
- Induction phase where three 5-day intensive sessions of chemotherapy over the course of six weeks.
- Local control phase with possible surgery or radiation for week 9-17.
- Maintenance phase for weeks 20-44 which consists of adminstering alternating drug therapies every three weeks.
Surgery
- Biopsy
- Hickman line
Chemotherapy
- Three cycles of ifosfamide 2 g/m2/d and etoposide 150 mg/m2/d administered intravenously on days 1 to 3,
- followed by CTX (cyclophosphamide) 1.5 g/m2 and doxorubicin 45 mg/m2 IV on day 5.
- Patients receive 5 hours of posthydration fluids with a solution of dextrose 5% in water with 0.5 normal saline iafter ifosfamide and 24 hours of posthydration fluids after CTX.
- Additionally, patients receive mesna at 25% of the oxazaphosphorine dose administered immediately and at 3 and 6 hours postdose.
- Twenty-four hours after chemotherapy, patients start granulocyte colony-stimulating factor (G-CSF) 10 ug/kg/dose for 10 to 14 days or until the ANC is 10.0 X 10 9/L or greater.
- Clinical Trial
- Phase 1 Clinical Trial 17-AAG
Alternative Therapy
- Chinese medicine of herbs and acupuncture to help with fluid retention and swelling.
[edit] Time Line
| Date | Test | Treatment | Chemicals | Result |
|---|---|---|---|---|
| 3/4/05 | 0 | Day surgery-biopsy | 0 | Evidence of disease mostly around intestines, in a cluster of lymph nodes between bladder and rectum, invasion of the liver, and a small area in chest. |
| 3/8/05 | Bone Scan/PET | 0 | 0 | Bones clear of cancer. PET indicates lympth node involvement from neck downwards. |
| 3/10/05 | 0 | Minor surgery for hickman line. Chemotherapy 1 | cyclophosphamide, doxorubicin, etoposide, ifosfamide | 0 |
| 4/1/05 | 0 | Chemotherapy 2 | cyclophosphamide, doxorubicin, etoposide, ifosfamide | 0 |
| 4/28/05 | 0 | 0 | 0 | Central line infection -Gram stain positive cocci and positive rods. |
| 5/2/05 | 0 | Chemotherapy 3 | ifosfamide, etoposide, cyclophosphamide, doxorubicin | 0 |
| 5/12/05 | 0 | 0 | 0 | Central line infection. |
| 5/12/05 | 0 | Surgery to remove central line. | 0 | 0 |
| 5/17/05 | 0 | Surgery to place new PICC line. | 0 | 0 |
| 5/19/05 | CT | 0 | 0 | Tumor did not respond to chemotherapy. There was some growth. Stopping current protocol. |
| 6/17/05 | 0 | Chemotherapy | Phase 1 Clinical Trial 17-AAG | 0 |
| 7/2/05 | CT | 0 | 0 | New chemo has not slowed disease progression. Retaining fluid in legs, ankles, & feet. |
| 7/17/05 | 0 | 0 | 0 | Progression of disease. Chinese medicine of herbs and acupuncture. |
| 7/25/05 | 0 | 0 | 0 | Passed Away |
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