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Wilson, M

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In Memory

Smsunfl Michael

Patient Information

Age: 14

Sex: Male

Diagnosed: 03/05

Location: Tennessee

Diagnosis: Disease around intestines, in a cluster of lymph nodes between bladder and rectum, and a small area in chest. DSRCT

Hospital - Vanderbilt Childrens Hospital

Oncologists
Jennifer Keates-Baleeiro, M.D.
John F. Kuttesch, Jr., M.D., Ph.D.

Passed Away: 07/25/05

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Treatment

Dose-Intensification for Pediatric Patients:

  • Induction phase where three 5-day intensive sessions of chemotherapy over the course of six weeks.
  • Local control phase with possible surgery or radiation for week 9-17.
  • Maintenance phase for weeks 20-44 which consists of adminstering alternating drug therapies every three weeks.

Surgery

  1. Biopsy
  2. Hickman line

Chemotherapy

  1. Three cycles of ifosfamide 2 g/m2/d and etoposide 150 mg/m2/d administered intravenously on days 1 to 3,
  2. followed by CTX (cyclophosphamide) 1.5 g/m2 and doxorubicin 45 mg/m2 IV on day 5.
  3. Patients receive 5 hours of posthydration fluids with a solution of dextrose 5% in water with 0.5 normal saline iafter ifosfamide and 24 hours of posthydration fluids after CTX.
  4. Additionally, patients receive mesna at 25% of the oxazaphosphorine dose administered immediately and at 3 and 6 hours postdose.
  5. Twenty-four hours after chemotherapy, patients start granulocyte colony-stimulating factor (G-CSF) 10 ug/kg/dose for 10 to 14 days or until the ANC is 10.0 X 10 9/L or greater.
  • Clinical Trial
  1. Phase 1 Clinical Trial 17-AAG

Alternative Therapy

  1. Chinese medicine of herbs and acupuncture to help with fluid retention and swelling.

Time Line

Date Test Treatment Chemicals Result
3/4/05 0 Day surgery-biopsy 0 Evidence of disease mostly around intestines, in a cluster of lymph nodes between bladder and rectum, invasion of the liver, and a small area in chest.
3/8/05 Bone Scan/PET 0 0 Bones clear of cancer. PET indicates lympth node involvement from neck downwards.
3/10/05 0 Minor surgery for hickman line. Chemotherapy 1 cyclophosphamide, doxorubicin, etoposide, ifosfamide 0
4/1/05 0 Chemotherapy 2 cyclophosphamide, doxorubicin, etoposide, ifosfamide 0
4/28/05 0 0 0 Central line infection -Gram stain positive cocci and positive rods.
5/2/05 0 Chemotherapy 3 ifosfamide, etoposide, cyclophosphamide, doxorubicin 0
5/12/05 0 0 0 Central line infection.
5/12/05 0 Surgery to remove central line. 0 0
5/17/05 0 Surgery to place new PICC line. 0 0
5/19/05 CT 0 0 Tumor did not respond to chemotherapy. There was some growth. Stopping current protocol.
6/17/05 0 Chemotherapy Phase 1 Clinical Trial 17-AAG 0
7/2/05 CT 0 0 New chemo has not slowed disease progression. Retaining fluid in legs, ankles, & feet.
7/17/05 0 0 0 Progression of disease. Chinese medicine of herbs and acupuncture.
7/25/05 0 0 0 Passed Away

5

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