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Diagnosis: Disease around intestines, in a cluster of lymph nodes between bladder and rectum, and a small area in chest. DSRCT
Hospital - Vanderbilt Childrens Hospital
Passed Away: 07/25/05
Dose-Intensification for Pediatric Patients:
- Induction phase where three 5-day intensive sessions of chemotherapy over the course of six weeks.
- Local control phase with possible surgery or radiation for week 9-17.
- Maintenance phase for weeks 20-44 which consists of adminstering alternating drug therapies every three weeks.
- Hickman line
- Three cycles of ifosfamide 2 g/m2/d and etoposide 150 mg/m2/d administered intravenously on days 1 to 3,
- followed by CTX (cyclophosphamide) 1.5 g/m2 and doxorubicin 45 mg/m2 IV on day 5.
- Patients receive 5 hours of posthydration fluids with a solution of dextrose 5% in water with 0.5 normal saline iafter ifosfamide and 24 hours of posthydration fluids after CTX.
- Additionally, patients receive mesna at 25% of the oxazaphosphorine dose administered immediately and at 3 and 6 hours postdose.
- Twenty-four hours after chemotherapy, patients start granulocyte colony-stimulating factor (G-CSF) 10 ug/kg/dose for 10 to 14 days or until the ANC is 10.0 X 10 9/L or greater.
- Clinical Trial
- Phase 1 Clinical Trial 17-AAG
- Chinese medicine of herbs and acupuncture to help with fluid retention and swelling.
|3/4/05||0||Day surgery-biopsy||0||Evidence of disease mostly around intestines, in a cluster of lymph nodes between bladder and rectum, invasion of the liver, and a small area in chest.|
|3/8/05||Bone Scan/PET||0||0||Bones clear of cancer. PET indicates lympth node involvement from neck downwards.|
|3/10/05||0||Minor surgery for hickman line. Chemotherapy 1||cyclophosphamide, doxorubicin, etoposide, ifosfamide||0|
|4/1/05||0||Chemotherapy 2||cyclophosphamide, doxorubicin, etoposide, ifosfamide||0|
|4/28/05||0||0||0||Central line infection -Gram stain positive cocci and positive rods.|
|5/2/05||0||Chemotherapy 3||ifosfamide, etoposide, cyclophosphamide, doxorubicin||0|
|5/12/05||0||0||0||Central line infection.|
|5/12/05||0||Surgery to remove central line.||0||0|
|5/17/05||0||Surgery to place new PICC line.||0||0|
|5/19/05||CT||0||0||Tumor did not respond to chemotherapy. There was some growth. Stopping current protocol.|
|6/17/05||0||Chemotherapy||Phase 1 Clinical Trial 17-AAG||0|
|7/2/05||CT||0||0||New chemo has not slowed disease progression. Retaining fluid in legs, ankles, & feet.|
|7/17/05||0||0||0||Progression of disease. Chinese medicine of herbs and acupuncture.|