- Dr. Frederick Frankenstein as Homer Simpson
- Igor as Principal Seymour Skinner
- The Monster as Barney Gumble
- Inga as Lisa Simpson
- Frau Blucher as Marge Simpson
- Elizabeth as Maude Flanders
- Inspector Kemp as Ned Flanders
- Herr Falkstein as Grandpa Abe Simpson
- Mr. Hilltop as Chief Clancy Wiggum
- Medical Student as Ralph Wiggum
- Harold as Mayor Joe Quimby
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